Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.32 |
| ▸ | CTPS1 | P17812 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365471 | 0.90 | ATR (0.36) | HDAC3HDAC1HDAC2CHRNA7POLB | |
| SCHEMBL19365521 | 0.90 | POLB (0.39) | HDAC1FAAHPOLBRAB9A | |
| SCHEMBL19670372 | 0.89 | HDAC1 (0.36) | HDAC3HDAC1HDAC2RAB9A | |
| SCHEMBL19365567 | 0.88 | HDAC1 (0.43) | HDAC3HDAC1HDAC2POLB | |
| SCHEMBL19365478 | 0.87 | HDAC3 (0.40) | HTR2AHTR2CHDAC3HDAC1HDAC2 | |
| SCHEMBL19365461 | 0.87 | HDAC1 (0.39) | HDAC3HDAC1HDAC2FAAHCHRNA7 | |
| SCHEMBL19706241 | 0.86 | HDAC2 (0.35) | HDAC3HDAC1HDAC2CTPS1 | |
| SCHEMBL19364807 | 0.86 | ATR (0.35) | HDAC3HDAC1HDAC2CHRNA7POLB | |
| SCHEMBL19364885 | 0.86 | PIK3C3 (0.35) | HDAC3HDAC1HDAC2 | |
| SCHEMBL19365556 | 0.85 | UBE2M (0.38) | HTR2AHTR2CHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590135-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | GABRA1 3990/4885ADRA2C 4718/4885HTR2A 4386/4885 |
| US-10590135-B2 | Substituted bridged urea analogs as sirtuin modulators | SIRT1, SIRT3, SIRT2 | GABRA1 3990/4885ADRA2C 4718/4885HTR2A 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.