Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365556 | 0.98 | UBE2M (0.38) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365519 | 0.92 | POLB (0.46) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365604 | 0.90 | HDAC1 (0.46) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365429 | 0.89 | POLB (0.36) | HDAC2POLBRAB9AUBE2MDCUN1D1 | |
| SCHEMBL19670509 | 0.88 | HDAC1 (0.41) | HDAC3HDAC1HDAC2POLBABL1 | |
| SCHEMBL19365451 | 0.87 | GABRA1 (0.36) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365471 | 0.87 | ATR (0.36) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365461 | 0.87 | HDAC1 (0.39) | HDAC3HDAC1HDAC2POLBRAB9A | |
| SCHEMBL19365728 | 0.85 | HDAC2 (0.43) | HDAC3HDAC1HDAC2POLBABL1 | |
| SCHEMBL19365778 | 0.85 | HDAC3 (0.39) | HDAC3HDAC1HDAC2POLBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |