Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.35 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.35 |
| ▸ | RPS17 | P08708 | 1/20 | 0.35 |
| ▸ | RPSA | P08865 | 1/20 | 0.35 |
| ▸ | RPS2 | P15880 | 1/20 | 0.35 |
| ▸ | RPL35A | P18077 | 1/20 | 0.35 |
| ▸ | RPL7 | P18124 | 1/20 | 0.35 |
| ▸ | RPL17 | P18621 | 1/20 | 0.35 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.35 |
| ▸ | RPS3 | P23396 | 1/20 | 0.35 |
| ▸ | RPS12 | P25398 | 1/20 | 0.35 |
| ▸ | RPL13 | P26373 | 1/20 | 0.35 |
| ▸ | RPL10 | P27635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632636 | 0.91 | GRM5 (0.41) | GRM5NR3C1ATRSYKLCK | |
| SCHEMBL19365323 | 0.87 | GRM5 (0.41) | GRM5ATRLMNA | |
| SCHEMBL19365764 | 0.86 | EGFR (0.44) | GRM5ATRBTKPIK3CA | |
| SCHEMBL19706072 | 0.84 | DYRK1A (0.41) | GRM5RPLP1RPLP0RPS17RPSA | |
| SCHEMBL19365441 | 0.83 | ATR (0.48) | ATRLMNA | |
| SCHEMBL19365577 | 0.83 | GRM5 (0.38) | GRM5ATRLCK | |
| SCHEMBL19364828 | 0.82 | SLC6A9 (0.41) | GRM5BTKLMNA | |
| SCHEMBL19670409 | 0.81 | PRMT5 (0.42) | GRM5ATRLCKLMNA | |
| SCHEMBL19365583 | 0.81 | ABL1 (0.38) | GRM5ATR | |
| SCHEMBL19365419 | 0.81 | EGFR (0.42) | GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |