Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706193 | 0.89 | CNR2 (0.40) | GRM5HDAC2ATR | |
| SCHEMBL19365577 | 0.88 | GRM5 (0.38) | GRM5SMN1; SMN2ATRSIRT2 | |
| SCHEMBL19670247 | 0.87 | PTGS1 (0.39) | TRPV1HDAC2 | |
| SCHEMBL19365428 | 0.86 | HDAC2 (0.48) | HDAC2ATRMAPK1 | |
| SCHEMBL19365705 | 0.83 | MAP4K4 (0.38) | TRPV1SMN1; SMN2MAP4K4FYN | |
| SCHEMBL19670283 | 0.80 | RAB9A (0.39) | SMN1; SMN2MAP4K4FYNMAPK1 | |
| SCHEMBL19365704 | 0.78 | SOAT2 (0.38) | TRPV1HDAC2TRPV3HSD17B14ATR | |
| SCHEMBL19670285 | 0.78 | BRAF (0.42) | ATR | |
| SCHEMBL20633236 | 0.77 | ATR (0.36) | HDAC2SMN1; SMN2ATRFYNSIRT2 | |
| SCHEMBL19706074 | 0.77 | SCN10A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |