Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365862 | 0.88 | KDM1A (0.40) | KMT2AALDH1A1MAPK1SMN1; SMN2CFTR | |
| SCHEMBL19365578 | 0.82 | BRAF (0.36) | ABL1CNR2PTGER4 | |
| SCHEMBL19365839 | 0.81 | CNR2 (0.51) | ALDH1A1CNR2 | |
| SCHEMBL19365796 | 0.80 | CNR2 (0.38) | ABL1ALDH1A1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL19365680 | 0.80 | TSHR (0.44) | ABL1KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL19365852 | 0.79 | MPL (0.41) | ABL1ALDH1A1CNR2 | |
| SCHEMBL19365679 | 0.79 | POLB (0.41) | KMT2AMEN1ALDH1A1RAB9APOLB | |
| SCHEMBL19365547 | 0.79 | ATR (0.35) | ABL1CNR2 | |
| SCHEMBL19365831 | 0.78 | P2RY1 (0.39) | ABL1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19365601 | 0.78 | CNR1 (0.36) | ABL1KMT2AMEN1CNR2CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |