Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618798 | 0.86 | FYN (0.36) | FYNCA2CA9HTR2AHTR2C | |
| SCHEMBL17624594 | 0.85 | TRPV1 (0.39) | FYNCA2CA9HTR2AHTR2C | |
| SCHEMBL19703434 | 0.83 | LPL (0.39) | CA2CA9HTR2AHTR2CKDM1A | |
| SCHEMBL17618355 | 0.83 | LPL (0.39) | CA2CA9HTR2AHTR2CKDM1A | |
| SCHEMBL19703431 | 0.83 | LPL (0.39) | CA2CA9HTR2AHTR2CKDM1A | |
| SCHEMBL17618702 | 0.83 | MEN1 (0.39) | CA2CA9HTR2AHTR2CKDM1A | |
| SCHEMBL16249970 | 0.82 | IDH2 (0.40) | CA2CA9HTR2AHTR2CMAPT | |
| SCHEMBL19865028 | 0.82 | IDH2 (0.40) | CA2CA9HTR2AHTR2CMAPT | |
| SCHEMBL17618378 | 0.82 | IDH2 (0.40) | CA2CA9HTR2AHTR2CMAPT | |
| SCHEMBL19365642 | 0.81 | FAAH (0.39) | CA2CA9ADORA2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |