Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504112 | 0.80 | MAOA (0.41) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL19366234 | 0.78 | SLC6A2 (0.39) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL19366426 | 0.76 | CHRNB2 (0.42) | HDAC4 | |
| SCHEMBL30312066 | 0.75 | MAOA (0.41) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL30312236 | 0.75 | MAOA (0.41) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL30311870 | 0.75 | MAOA (0.41) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL19366430 | 0.74 | HDAC4 (0.60) | HDAC4MEN1KMT2AKDM1AKDM1B | |
| SCHEMBL8435497 | 0.70 | MAOA (0.41) | HDAC4MEN1KMT2AKDM1AMAOA | |
| SCHEMBL21208288 | 0.68 | MAOA (0.35) | HDAC4MEN1KMT2AMAOAMAOB | |
| SCHEMBL12498302 | 0.67 | HDAC4 (1.00) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |