Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504112 | 0.73 | MAOA (0.41) | KMT2AMAOAMAOBMEN1LMNA | |
| SCHEMBL9100356 | 0.72 | TDP1 (0.43) | HSD17B10CUL4ATDP1ALDH1A1KDM4E | |
| SCHEMBL9100348 | 0.72 | TDP1 (0.43) | HSD17B10CUL4ATDP1ALDH1A1KDM4E | |
| SCHEMBL12694394 | 0.72 | GAA (0.46) | HSD17B10TDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL16796701 | 0.72 | DNMT3B (0.40) | HSD17B10CUL4ATDP1ALDH1A1KDM4E | |
| SCHEMBL19366234 | 0.71 | SLC6A2 (0.39) | HSD17B10TDP1ALDH1A1KMT2AMAOA | |
| SCHEMBL30335476 | 0.70 | NR4A1 (0.44) | CUL4ATDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL19366232 | 0.69 | HDAC4 (0.50) | KDM4EKMT2AMAOAMAOBMEN1 | |
| SCHEMBL11451918 | 0.69 | GPR35 (0.50) | HSD17B10CUL4ATDP1ALDH1A1KDM4E | |
| SCHEMBL11451916 | 0.69 | GPR35 (0.50) | HSD17B10CUL4ATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |