Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 8/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19366606 | 0.87 | MAP2K1 (0.34) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL19367459 | 0.84 | MAP2K1 (0.34) | MAP2K1MAP2K2 | |
| SCHEMBL19366763 | 0.83 | MAP2K1 (0.34) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL20034583 | 0.83 | MAP2K1 (0.49) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL19366554 | 0.76 | RIPK2 (0.40) | RIPK2FLT1KDR | |
| SCHEMBL15129345 | 0.73 | MAP2K1 (0.59) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL19367408 | 0.72 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL19366557 | 0.70 | MAP2K1 (0.33) | MAP2K1MAP2K2 | |
| SCHEMBL19367194 | 0.70 | MAP2K1 (0.49) | MAP2K1MAP2K2MAP2K5FLT1KDR | |
| SCHEMBL20034606 | 0.69 | MAP2K1 (0.49) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804855-B1 | BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF | SHANGHAI KECHOW PHARMA INC (CN) | 2017-09-20 | — | — | EP | disclosed |