Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169212 | 0.88 | CHEK1 (0.58) | SMN1; SMN2CHEK1RAB9ANPC1GAA | |
| Bromide SCHEMBL1146428 | 0.87 | CHEK1 (0.57) | SMN1; SMN2CHEK1RAB9ANPC1GAA | |
| SCHEMBL12670720 | 0.85 | LMNA (0.60) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL12632188 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL7543278 | 0.85 | RAB9A (0.66) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL7431224 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL2553528 | 0.82 | SMN1; SMN2 (0.83) | SMN1; SMN2RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL1937653 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2CHEK1RAB9ANPC1CYP1A2 | |
| SCHEMBL8043279 | 0.81 | RAB9A (0.61) | SMN1; SMN2RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL2558958 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9ANPC1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167507-A1 | CYSTEINE PROTEASE INHIBITORS | Medivir AB (SE) | 2010-03-31 | — | — | EP | claimed |
| WO-2009000877-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2008-12-31 | — | — | WO | claimed |
| WO-2001068645-A2 | N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-09-20 | — | — | WO | claimed |
| EP-2331548-A1 | PROTEASE INHIBITORS | Medivir AB (SE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010034788-A1 | PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2008114054-A1 | PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2008-09-25 | — | — | WO | disclosed |
| WO-2001068645-A2 | N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-09-20 | — | — | WO | disclosed |