Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17183746 | 0.84 | NPC1 (0.54) | TAAR1TGM2CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL28717475 | 0.82 | TGM2 (0.48) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL1924441 | 0.79 | KCNA3 (0.65) | KCNA3TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17183649 | 0.78 | MTNR1A (0.48) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL19557264 | 0.78 | KCNA3 (0.56) | KCNA3TAAR1ALDH1A1NPC1RAB9A | |
| SCHEMBL8943316 | 0.78 | TGM2 (0.44) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL24163953 | 0.76 | KCNA3 (0.55) | KCNA3TAAR1NPC1RAB9AAPAF1 | |
| SCHEMBL9836276 | 0.76 | TGM2 (0.40) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL17183720 | 0.75 | MTNR1A (0.49) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL10408489 | 0.74 | MDM2 (0.47) | TGM2CYP2C19ALDH1A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884048-B2 | ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170266167-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266167-A1 | ERK INHIBITORS | MAPK1, MAPK3, MAPK6 | KCNA3 4549/4885TAAR1 2508/4885TGM2 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.