Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056834 | 0.85 | CRBN (0.61) | CRBNCYP17A1CYP3A4HDAC8HDAC6 | |
| SCHEMBL13702375 | 0.85 | HDAC8 (0.68) | CRBNCYP17A1CYP3A4HDAC8HDAC6 | |
| SCHEMBL723332 | 0.83 | HDAC8 (0.70) | CRBNHDAC8HDAC6CDK8PDK2 | |
| SCHEMBL19391346 | 0.83 | HDAC2 (0.53) | HDAC8HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24807366 | 0.83 | KIF11 (0.45) | RXRARXRBRXRGHDAC8HDAC6 | |
| SCHEMBL14210412 | 0.82 | CRBN (0.58) | CRBNCYP17A1CYP3A4HDAC8HDAC6 | |
| SCHEMBL15638622 | 0.82 | MEN1 (0.62) | CRBNCYP17A1CYP3A4HDAC8HDAC6 | |
| SCHEMBL2627836 | 0.82 | RXRA (0.71) | RXRARXRBRXRGPTPN5ERN1 | |
| SCHEMBL276759 | 0.82 | HDAC8 (0.59) | CYP3A4RXRARXRBRXRGHDAC8 | |
| SCHEMBL12168604 | 0.81 | EPHX2 (0.60) | CRBNRXRARXRBRXRGHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |