Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.37 |
| ▸ | TACR1 | P25103 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27834011 | 0.94 | SLC6A4 (0.39) | PDK1HTR4SLC6A4TACR1SLC6A2 | |
| Fumaric Acid SCHEMBL2388946 | 0.94 | SLC6A4 (0.39) | PDK1HTR4SLC6A4TACR1SLC6A2 | |
| SCHEMBL1937662 | 0.90 | SLC6A4 (0.46) | PDK1HTR4SLC6A4TACR1ACHE | |
| SCHEMBL2396274 | 0.89 | PDK1 (0.39) | PDK1SLC6A4TACR1MEN1ALDH1A1 | |
| SCHEMBL1937163 | 0.86 | HTR4 (0.41) | HTR4ACHEMEN1ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL1937560 | 0.84 | SLC6A4 (0.42) | PDK1HTR4SLC6A4TACR1SLC6A2 | |
| SCHEMBL2544643 | 0.83 | SLC6A4 (0.47) | PDK1HTR4SLC6A4TACR1ITGB3 | |
| Fumaric Acid SCHEMBL1936564 | 0.83 | SLC6A4 (0.39) | PDK1SLC6A4TACR1SLC6A2SLC6A3 | |
| SCHEMBL1937232 | 0.81 | SLC6A4 (0.44) | PDK1HTR4SLC6A4TACR1ACHE | |
| Fumaric Acid SCHEMBL1937182 | 0.81 | HTR4 (0.37) | HTR4ACHELMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NEUROSEARCH A/S (DK) | 2011-09-08 | — | — | US | claimed |
| CN-102131780-A | Novel piperidine-propionamide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH AS | 2011-07-20 | — | — | CN | claimed |
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NEUROSEARCH A/S (DK) | 2011-09-08 | — | — | US | disclosed |
| CN-102131780-A | Novel piperidine-propionamide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH AS | 2011-07-20 | — | — | CN | disclosed |
| EP-2331504-A2 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NeuroSearch A/S (DK) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010023196-A2 | NOVEL PIPERIDINE-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | SLC18A2, SLC1A2, PNMT | PDK1 358/4885HTR4 16/4885SLC6A4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.