Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13754456 | 0.83 | CA2 (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19369657 | 0.83 | NOS2 (0.38) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14270199 | 0.81 | HDAC3 (0.55) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL21087169 | 0.81 | HDAC8 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL21118382 | 0.81 | HDAC3 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14551994 | 0.81 | CYP4F2 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL17585416 | 0.80 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14189703 | 0.79 | HDAC3 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| Acetic Acid SCHEMBL29114915 | 0.79 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20542578 | 0.77 | TDP1 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017189342-A1 | INSULIN DIMER-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2017-11-02 | — | — | WO | disclosed |
| WO-2017160669-A1 | INSULIN-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | WO | disclosed |