Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 12/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19370702 | 0.80 | ESR2 (0.41) | — | |
| SCHEMBL24266854 | 0.79 | MAPT (0.40) | MEN1KMT2A | |
| SCHEMBL19370652 | 0.79 | HSD17B3 (0.37) | NAMPTMEN1KMT2ACARM1 | |
| SCHEMBL19370816 | 0.77 | KCNH2 (0.43) | CARM1KCNH2HRH3 | |
| SCHEMBL26003508 | 0.77 | AKR1C3 (0.35) | NOTUMNAMPTMEN1KMT2AKCNH2 | |
| SCHEMBL19370821 | 0.77 | ESR1 (0.44) | NOTUMNAMPT | |
| SCHEMBL19370918 | 0.76 | SCN9A (0.39) | NOTUMNAMPTKCNH2 | |
| SCHEMBL22698792 | 0.75 | ALDH1A1 (0.47) | MEN1KMT2A | |
| SCHEMBL22461261 | 0.72 | ALDH1A1 (0.39) | MEN1KMT2A | |
| SCHEMBL23129062 | 0.70 | MAPT (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161119-A1 | SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-09-21 | — | — | WO | disclosed |