Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29607421 | 0.85 | GAA (1.00) | GAAMEN1ALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL11432099 | 0.82 | SIGMAR1 (0.60) | GAAMEN1KMT2ASIGMAR1HRH3 | |
| SCHEMBL22623804 | 0.80 | DDB1 (0.71) | GAAMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL16429902 | 0.77 | KMT2A (0.64) | MEN1ALDH1A1KMT2ASIGMAR1HRH3 | |
| SCHEMBL19359333 | 0.76 | POLB (0.59) | GAAMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL19359354 | 0.76 | GAA (0.56) | GAAALDH1A1 | |
| SCHEMBL3714297 | 0.73 | SIGMAR1 (0.75) | MEN1KMT2ASIGMAR1HRH3GSK3A | |
| SCHEMBL28967239 | 0.73 | GSK3A (0.64) | GAAMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL6101068 | 0.73 | GAA (0.73) | GAAMEN1ALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL19359486 | 0.72 | DDB1 (0.67) | GAASIGMAR1GSK3AGSK3BDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161119-A1 | SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-09-21 | — | — | WO | disclosed |