Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16429902 | 0.91 | KMT2A (0.64) | SIGMAR1HRH3KMT2AMEN1TDP1 | |
| SCHEMBL11432095 | 0.83 | GAA (0.68) | SIGMAR1KMT2AMEN1GSK3AGSK3B | |
| SCHEMBL19370960 | 0.82 | GAA (0.74) | SIGMAR1HRH3KMT2AMEN1GSK3A | |
| SCHEMBL11513541 | 0.78 | NPC1 (0.58) | SIGMAR1KMT2AMEN1TDP1GSK3A | |
| SCHEMBL28967239 | 0.77 | GSK3A (0.64) | SIGMAR1HRH3KMT2AMEN1GSK3A | |
| SCHEMBL3714297 | 0.77 | SIGMAR1 (0.75) | SIGMAR1HRH3KMT2AMEN1TDP1 | |
| SCHEMBL9491484 | 0.77 | MTNR1A (0.63) | HRH3KMT2AMEN1TDP1MAOA | |
| SCHEMBL10195154 | 0.74 | GSK3A (0.64) | SIGMAR1HRH3KMT2AMEN1GSK3A | |
| SCHEMBL3459387 | 0.74 | L3MBTL1 (0.64) | SIGMAR1HRH3KMT2AMEN1GSK3A | |
| SCHEMBL4509396 | 0.74 | ACACB (0.64) | SIGMAR1HRH3KMT2AMEN1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023097-A1 | De-arylmethylation of N-mono- or N-diarylmethyl-beta-lactams; novel azetizinones having anti-bacterial activity | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-01-28 | — | — | EP | disclosed |
| US-4163743-A | Beta-lactams, their production from azetidine carboxylic acids, intermediates thereto and derivatives thereof | RESEARCH CORPORATION (US) | 1979-08-07 | — | — | US | disclosed |