Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2147139 | 0.88 | RAB9A (0.66) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2147609 | 0.88 | RAB9A (0.66) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2147012 | 0.88 | RAB9A (0.66) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| SCHEMBL2621291 | 0.88 | MAPT (0.70) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| SCHEMBL31276462 | 0.88 | MAPT (0.70) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Bromide SCHEMBL9239377 | 0.86 | MAPT (0.68) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Ethane SCHEMBL2147606 | 0.84 | MAPT (0.48) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19372018 | 0.81 | RAB9A (0.56) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| Acetic Acid SCHEMBL9270113 | 0.79 | NPC1 (0.58) | RAB9AMAPTNPC1TP53SMN1; SMN2 | |
| SCHEMBL31276277 | 0.74 | MAPT (0.78) | RAB9AMAPTNPC1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526129-B1 | ETHYLENE POLYMERISATION PROCESS | SAUDI BASIC IND CORP (SABIC) (SA) | 2017-09-27 | — | — | EP | disclosed |