Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719809 | 0.93 | NPC1 (0.67) | ALDH1A1MEN1KMT2AGAAALOX12 | |
| SCHEMBL18737568 | 0.83 | L3MBTL1 (0.51) | ALDH1A1MEN1KMT2AGAANPC1 | |
| SCHEMBL5853157 | 0.80 | NPC1 (0.88) | ALDH1A1MEN1KMT2AGAAALOX12 | |
| SCHEMBL18737741 | 0.80 | MEN1 (0.46) | MEN1KMT2ARAB9ASMN1; SMN2PTPN1 | |
| SCHEMBL3343137 | 0.78 | ALOX12 (0.67) | ALDH1A1MEN1KMT2AGAAALOX12 | |
| SCHEMBL15832155 | 0.78 | SMN1; SMN2 (0.57) | ALDH1A1MEN1KMT2AGAAALOX12 | |
| SCHEMBL13764412 | 0.75 | CA2 (0.51) | ALDH1A1HPGDPTPN1MAOBMAOA | |
| SCHEMBL22096632 | 0.74 | ALOX12 (0.52) | ALDH1A1MEN1KMT2AGAAALOX12 | |
| SCHEMBL23747455 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13720058 | 0.73 | NPC1 (1.00) | ALDH1A1MEN1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2017-09-20 | — | — | EP | disclosed |