Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.41 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 8/20 | 0.40 |
| ▸ | PPARA | Q07869 | 7/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21499691 | 0.82 | TRPC5 (0.47) | P2RX3TRPC5TRPC1TRPC4PPARG | |
| SCHEMBL19375216 | 0.81 | TRPC5 (0.45) | P2RX3TRPC5TRPC1TRPC4PPARG | |
| SCHEMBL21316333 | 0.76 | P2RX3 (0.40) | P2RX3TRPC5TRPC1TRPC4PPARG | |
| SCHEMBL16028430 | 0.75 | ATM (0.50) | P2RX3TRPC5TRPC1TRPC4CYP2C9 | |
| SCHEMBL16028002 | 0.72 | TRPC5 (0.61) | P2RX3TRPC5TRPC1TRPC4KCNH2 | |
| SCHEMBL20432001 | 0.72 | POLB (0.39) | P2RX3 | |
| SCHEMBL16076247 | 0.71 | TRPC5 (0.65) | P2RX3TRPC5TRPC1TRPC4PPARG | |
| SCHEMBL16028115 | 0.71 | TRPC5 (0.74) | P2RX3TRPC5TRPC1TRPC4KCNH2 | |
| SCHEMBL19505218 | 0.71 | TLR7 (0.36) | P2RX3 | |
| SCHEMBL20432324 | 0.70 | BRD4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |