Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19505135 | 0.90 | SCN9A (0.41) | KCNH2SCN9ASCN5ATRPC1TRPC4 | |
| SCHEMBL19375596 | 0.85 | TRPC5 (0.50) | KCNH2TRPC1TRPC4TRPC5P2RX3 | |
| SCHEMBL21499642 | 0.84 | P2RX3 (0.44) | TRPC1TRPC4TRPC5P2RX3HCRTR1 | |
| SCHEMBL19505365 | 0.83 | TRPC5 (0.42) | KCNH2SCN9ASCN5ATRPC1TRPC4 | |
| SCHEMBL21316294 | 0.79 | TRPC5 (0.50) | KCNH2TRPC1TRPC4TRPC5P2RX3 | |
| SCHEMBL21316267 | 0.78 | TRPC1 (0.36) | TRPC1TRPC4TRPC5GRIN1GRIN2B | |
| SCHEMBL19505138 | 0.77 | TRPC5 (0.43) | SCN9ASCN5ATRPC1TRPC4TRPC5 | |
| SCHEMBL16027906 | 0.77 | TRPC5 (0.59) | KCNH2TRPC1TRPC4TRPC5GRIN1 | |
| SCHEMBL21499637 | 0.77 | SCN9A (0.43) | KCNH2SCN9ASCN5AKCNN4 | |
| SCHEMBL21316291 | 0.77 | TRPC5 (0.54) | KCNH2TRPC1TRPC4TRPC5P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |