Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.44 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.43 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21316294 | 0.94 | TRPC5 (0.50) | P2RX3TRPC1TRPC4TRPC5ENPP2 | |
| SCHEMBL19375596 | 0.88 | TRPC5 (0.50) | P2RX3TRPC1TRPC4TRPC5ENPP2 | |
| SCHEMBL19375184 | 0.87 | TRPC5 (0.49) | P2RX3TRPC1TRPC4TRPC5CETP | |
| SCHEMBL18834464 | 0.86 | TRPC1 (0.42) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL21316291 | 0.86 | TRPC5 (0.54) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL19560554 | 0.84 | TRPC1 (0.49) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL19375620 | 0.84 | KCNH2 (0.37) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL19505055 | 0.83 | TRPC5 (0.56) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL21499665 | 0.83 | TRPC5 (0.51) | P2RX3TRPC1TRPC4TRPC5HCRTR1 | |
| SCHEMBL19505138 | 0.83 | TRPC5 (0.43) | P2RX3TRPC1TRPC4TRPC5HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230040259-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, LLC (US) | 2023-02-09 | — | — | US | disclosed |
| US-11208409-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, LLC (US) | 2021-12-28 | — | — | US | disclosed |
| US-20190322667-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230040259-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | P2RX3 30/4885TRPC1 4/4885TRPC4 3/4885 |
| US-11208409-B2 | Substituted xanthines and methods of use thereof | TRPC5, TRPC7, TRPC4 | P2RX3 30/4885TRPC1 4/4885TRPC4 3/4885 |
| US-20190322667-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | P2RX3 30/4885TRPC1 4/4885TRPC4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.