Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.54 |
| ▸ | KDM4A | O75164 | 2/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.54 |
| ▸ | TET3 | O43151 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimelic Acid SCHEMBL3223934 | 0.98 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Adipic Acid SCHEMBL28234949 | 0.98 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Malic Acid SCHEMBL7895521 | 0.95 | SMN1; SMN2 (0.75) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Cadaverine Tartrate SCHEMBL27687433 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Malic Acid SCHEMBL28105083 | 0.90 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Malic Acid SCHEMBL4814892 | 0.90 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Adipic Acid SCHEMBL5527303 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Adipic Acid SCHEMBL5527315 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Stearic Acid SCHEMBL3379301 | 0.88 | GPR84 (0.65) | SMN1; SMN2TSHRSLC22A6GPR84FFAR1 | |
| Octanoic Acid SCHEMBL31240956 | 0.88 | GPR84 (0.65) | SMN1; SMN2TSHRSLC22A6GPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63169966-A | — | — | None | — | — | JP | disclosed |
| WO-2020056553-A1 | METHOD FOR PREPARARING HETEROCYCLIC COMPOUND AND SALTS THEREOF | 海门华祥医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |
| EP-2346347-B1 | USE OF A POLYESTER AS AN ELASTOMER COMPONENT FOR GUM BASES | GUMLINK AS (DK) | 2014-11-12 | — | — | EP | disclosed |
| EP-2346347-A1 | USE OF A POLYESTER AS AN ELASTOMER COMPONENT FOR GUM BASES | Gumlink A/S (DK) | 2011-07-27 | — | — | EP | disclosed |
| US-20110160424-A1 | Use Of A Polyester As An Elastomer Component For Gum Bases | GUMLINK A/S (DK) | 2011-06-30 | — | — | US | disclosed |
| WO-2010025725-A1 | USE OF A POLYESTER AS AN ELASTOMER COMPONENT FOR GUM BASES | GUMLINK A/S (DK) | 2010-03-11 | — | — | WO | disclosed |
| EP-2160949-A1 | Use of a polyester as an elastomer component for gum bases | Gumlink A/S (DK) | 2010-03-10 | — | — | EP | disclosed |
| CN-1183046-C | Method of purifying water, suitable bacteria for said method and use thereof | — | 2005-01-05 | — | — | CN | disclosed |
| CN-1420848-A | Water treatment method, microorganism suitable for the method and use thereof | CLEVO OY (FI) | 2003-05-28 | — | — | CN | disclosed |
| WO-2000005352-A1 | PSEUDOMONAS SP. GK-15 AND PROTEASE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |
| US-5064656-A | Swelling disintegrant of starch or crosslinked polyvinylpyrrolidone and effervescant | DR. GERGELY & CO. (CH) | 1991-11-12 | — | — | US | disclosed |
| JP-S63169966-A | COMPOSITION FOR IMPROVING SPRINGINESS OF MEAT PASTE PRODUCT | CHIBA SEIFUN KK | 1988-07-13 | — | — | JP | disclosed |