Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | HTR6 | P50406 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 7/20 | 0.52 |
| ▸ | HTR2C | P28335 | 7/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | KCNA1 | Q09470 | 3/20 | 0.49 |
| ▸ | KCNAB1 | Q14722 | 3/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377375 | 1.00 | ROCK2 (0.55) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377077 | 0.92 | IDH1 (0.52) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377040 | 0.92 | IDH1 (0.52) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377195 | 0.88 | DRD2 (0.53) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377153 | 0.88 | DRD2 (0.51) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377300 | 0.84 | DRD2 (0.49) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377073 | 0.84 | DRD2 (0.52) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377031 | 0.84 | DRD2 (0.52) | ROCK2DRD2DRD3HTR6HTR2A | |
| SCHEMBL19377193 | 0.82 | ROCK2 (0.53) | ROCK2DRD2DRD3CYP2C9HSD17B10 | |
| SCHEMBL19377191 | 0.82 | ROCK2 (0.53) | ROCK2DRD2DRD3CYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275301-A1 | Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | US | claimed |
| US-20170275301-A1 | Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | US | disclosed |
| US-20170275301-A1 | Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | US | disclosed |
| WO-2017162390-A1 | BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275301-A1 | Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof | UTS2R, GHSR, GRPR | ROCK2 4208/4885DRD2 4443/4885DRD3 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.