Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295735 | 0.88 | MCL1 (0.47) | PDK2MCL1ACMSDHDAC8HDAC6 | |
| SCHEMBL10034424 | 0.86 | MCL1 (0.40) | PDK2MCL1ACMSDHDAC8HDAC6 | |
| SCHEMBL6292662 | 0.85 | PDK2 (0.51) | PDK2 | |
| SCHEMBL14269410 | 0.85 | PDK2 (0.51) | PDK2 | |
| SCHEMBL13045495 | 0.84 | EDNRB (0.46) | MCL1ACMSDHDAC8HDAC6ENPP3 | |
| SCHEMBL16852598 | 0.82 | FLT3 (0.36) | PDK2MCL1ACMSDHDAC8HDAC6 | |
| SCHEMBL19822252 | 0.82 | PDK2 (0.44) | PDK2CA1CA2ALDH1A1CYP1A2 | |
| SCHEMBL19797303 | 0.82 | PDK2 (0.44) | PDK2CA1CA2ALDH1A1CYP1A2 | |
| SCHEMBL28543533 | 0.82 | MCL1 (0.39) | PDK2MCL1ACMSDHDAC8HDAC6 | |
| SCHEMBL12781932 | 0.82 | PDK2 (0.49) | PDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-04-11 | — | — | US | disclosed |
| WO-2017157983-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | TEC, NUDT1, DPYD | PDK2 157/4885MCL1 4622/4885ACMSD 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.