Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.47 |
| ▸ | TEK | Q02763 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.47 |
| ▸ | PRKDC | P78527 | 6/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.47 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200349 | 0.81 | NUDT14 (0.62) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL29439185 | 0.80 | NUDT14 (0.61) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL29611096 | 0.79 | PIK3CD (0.48) | LCKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15519110 | 0.79 | PIK3CD (0.48) | LCKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22692856 | 0.78 | ERBB2 (0.50) | LCKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17626717 | 0.78 | PIK3CD (0.47) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30387716 | 0.78 | PIK3CD (0.65) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30415900 | 0.78 | FYN (0.47) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL22692848 | 0.78 | FYN (0.47) | LCKTEKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13064025 | 0.77 | PIK3CD (0.53) | LCKTEKPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327504-A1 | Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines | SANDOZ AG (CH) | 2017-11-16 | — | — | US | disclosed |
| US-20170327504-A1 | Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines | SANDOZ AG (CH) | 2017-11-16 | — | — | US | disclosed |
| WO-2017163257-A1 | PROCESS FOR PREPARING PURE LH-PYRAZOLO[3,4-D] PYRIMIDINE DERIVATIVE | IND-SWIFT LABORATORIES LIMITED (IN) | 2017-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327504-A1 | Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines | BTK, ABL1, SYK | LCK 10/4885TEK 868/4885PIK3CD 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.