Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.45 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17200288 | 0.85 | DRD1 (0.49) | DRD1USP7 | |
| SCHEMBL19390819 | 0.83 | DRD1 (0.46) | DRD1HSP90AB1GAA | |
| SCHEMBL15698836 | 0.82 | DRD1 (0.58) | DRD1USP8 | |
| SCHEMBL19479326 | 0.81 | DRD1 (0.57) | DRD1USP8 | |
| SCHEMBL20171985 | 0.79 | HSP90AB1 (0.43) | DRD1HSP90AB1USP8USP7EGLN2 | |
| SCHEMBL15705497 | 0.79 | DRD1 (0.55) | DRD1 | |
| SCHEMBL15666826 | 0.74 | DRD1 (0.51) | DRD1USP7 | |
| SCHEMBL15696157 | 0.72 | DRD1 (0.60) | DRD1USP8USP7 | |
| SCHEMBL19479286 | 0.71 | DRD1 (0.59) | DRD1USP8USP7EGLN2 | |
| SCHEMBL29770983 | 0.70 | ALOX15 (0.45) | DRD1USP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |