Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | USP8 | P40818 | 2/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17178242 | 0.82 | DRD1 (0.46) | USP8DRD1MEN1KMT2AKDM4E | |
| SCHEMBL15698821 | 0.82 | DRD1 (0.46) | DRD1EGLN2 | |
| SCHEMBL19390810 | 0.79 | DRD1 (0.51) | HSP90AB1USP8USP7GAADRD1 | |
| SCHEMBL17174385 | 0.79 | DRD1 (0.43) | DRD1EGLN2 | |
| SCHEMBL15698831 | 0.74 | EGFR (0.45) | USP8GAAKDM4EALDH1A1LMNA | |
| SCHEMBL19390775 | 0.73 | ESR1 (0.40) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL19374582 | 0.70 | KDM4E (0.43) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20392937 | 0.69 | CRHR1 (0.38) | USP8GAADRD1KMT2AKDM4E | |
| SCHEMBL6170131 | 0.69 | NOS3 (0.46) | USP8GAAKDM4ENOS3NOS2 | |
| SCHEMBL252008 | 0.69 | CYP11B1 (0.37) | USP8DRD1ALOX15LRRK2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |