Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24589250 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL20830065 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL11448434 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL11448424 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL10707162 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL25510109 | 0.71 | ALDH1A1 (0.46) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL11232945 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL13516465 | 0.71 | RAB9A (0.61) | ALDH1A1KDM4EHTTLMNAL3MBTL1 | |
| SCHEMBL2581418 | 0.71 | LMNA (0.52) | ALDH1A1KDM4EHTTCES2CES1 | |
| SCHEMBL25279464 | 0.71 | LMNA (0.52) | ALDH1A1KDM4EHTTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3024821-B1 | PROCESS FOR THE PREPARATION OF PERAMPANEL | TEVA PHARMACEUTICALS INT GMBH (CH) | 2017-09-27 | — | — | EP | disclosed |