Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17777429 | 0.88 | KMT2A (0.47) | KMT2AMEN1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL14703240 | 0.87 | MEN1 (0.46) | KMT2AMEN1L3MBTL1LMNAEPHX2 | |
| SCHEMBL17777459 | 0.84 | CHKA (0.44) | KMT2AMEN1LMNAEPHX2ALDH1A1 | |
| SCHEMBL19393859 | 0.84 | MEN1 (0.44) | KMT2AMEN1LMNAALDH1A1HPGD | |
| SCHEMBL14703473 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19393815 | 0.78 | RAB9A (0.45) | KMT2AMEN1LMNAEPHX2ALDH1A1 | |
| SCHEMBL16692427 | 0.78 | MEN1 (0.41) | KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL17777323 | 0.78 | KMT2A (0.44) | KMT2AMEN1LMNAHRH4 | |
| SCHEMBL16692437 | 0.78 | P2RX7 (0.41) | KMT2AMEN1LMNA | |
| SCHEMBL5465071 | 0.77 | MEN1 (1.00) | KMT2AMEN1L3MBTL1LMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222614-B1 | BIGUANIDE COMPOUND AND USE THEREOF | IMMUNOMET THERAPEUTICS INC (US) | 2020-07-29 | — | — | EP | disclosed |
| EP-3222614-A2 | BIGUANIDE COMPOUND AND USE THEREOF | Immunomet Therapeutics Inc. (US) | 2017-09-27 | — | — | EP | disclosed |