Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19279396 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1F2LMNASMPD2 | |
| SCHEMBL9358736 | 0.81 | HMGCR (0.44) | KDM4EHMGCRNR1I2ALDH1A1L3MBTL1 | |
| SCHEMBL19279399 | 0.79 | NR1I2 (0.66) | KDM4EHMGCRNR1I2ALDH1A1LMNA | |
| SCHEMBL11046152 | 0.73 | KDM4E (0.47) | KDM4ENR1I2ALDH1A1F2LMNA | |
| SCHEMBL10888977 | 0.73 | KDM4E (0.47) | KDM4ENR1I2ALDH1A1F2LMNA | |
| SCHEMBL11515536 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1HDAC8L3MBTL1MAPT | |
| SCHEMBL19398053 | 0.72 | NR1I2 (0.56) | KDM4EHMGCRNR1I2ALDH1A1LMNA | |
| SCHEMBL20852695 | 0.70 | NR1I2 (0.53) | KDM4ENR1I2ALDH1A1LMNAMTNR1A | |
| SCHEMBL10662062 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1F2LMNASMPD2 | |
| SCHEMBL20182010 | 0.68 | KDM4E (0.55) | KDM4EHMGCRALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377781-B2 | Alkylidene phosphonate esters as p-glycoprotein inducers | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2019-08-13 | — | — | US | disclosed |
| US-20170275314-A1 | ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-28 | — | — | US | disclosed |
| US-20170275314-A1 | ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377781-B2 | Alkylidene phosphonate esters as p-glycoprotein inducers | ABCB1, ABCC2, ABCC4 | KDM4E 3375/4885HMGCR 307/4885NR1I2 87/4885 |
| US-20170275314-A1 | ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS | ABCB1, ABCC2, ABCC4 | KDM4E 3375/4885HMGCR 307/4885NR1I2 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.