SCHEMBL19400459

SCHEMBL19400459

Cc1cc2cc3c(C)cc(O)cc3cc2c(C)c1O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.37
CHRM1 P11229 1/20 0.37
ALOX15 P16050 1/20 0.37
MAOA P21397 1/20 0.37
TBXA2R P21731 1/20 0.37
ADRA1A P35348 1/20 0.37
HTR2B P41595 1/20 0.37
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
KDM4E B2RXH2 4/20 0.33
LMNA P02545 2/20 0.33
HTT P42858 2/20 0.33
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
MITF O75030 1/20 0.33
TP53 P04637 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19012009 0.81 ESR1 (0.50) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL13021187 0.81 LDHA (0.45) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL21985694 0.77 CYP1A2 (0.46) CYP3A4CYP1A2LMNAHTTTSHR
SCHEMBL21985687 0.73 ESR1 (0.42) CYP1A2CYP2C9KDM4ELMNAHTT
SCHEMBL31433385 0.72 DYRK1A (0.54) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL6130143 0.70 LDHA (0.52) CYP3A4CYP1A2CYP2C9CYP2C19CA1
SCHEMBL22339 0.69 CA1 (0.65) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL15835617 0.69 ESR1 (0.55) CYP1A2CYP2C9CYP2C19CA1CA2
SCHEMBL9623383 0.68 ESR2 (0.52) CYP3A4CHRM1ALOX15MAOATBXA2R
Methane SCHEMBL8857034 0.67 CA1 (0.61) CYP3A4CHRM1ALOX15MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3433236-B1 CYANOPYRIMIDINE DERIVATIVES SUITABLE AS COMPONENTS IN LIQUID CRYSTAL MEDIA MERCK PATENT GMBH (DE) 2021-10-27 EP disclosed
EP-3529331-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-10-07 EP disclosed
EP-3504293-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-05-13 EP disclosed
WO-2017162707-A1 CYANOPYRIMIDINE DERIVATIVES SUITABLE AS COMPONENTS IN LIQUID CRYSTAL MEDIA MERCK PATENT GMBH (DE) 2017-09-28 WO disclosed
WO-2017162716-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-09-28 WO disclosed