Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939373 | 0.91 | ALDH1A1 (0.40) | MAPTLMNAS1PR1KDM4EPOLB | |
| SCHEMBL1379055 | 0.89 | KDM4E (0.48) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1941032 | 0.88 | KMT2A (0.40) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1938936 | 0.88 | ALDH1A1 (0.39) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1938878 | 0.88 | MAPT (0.39) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1939247 | 0.87 | MAPT (0.41) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL5039141 | 0.84 | KDM4E (0.49) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL5032676 | 0.84 | ALDH1A1 (0.45) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL5034997 | 0.83 | KDM4E (0.41) | MAPTLMNAKDM4ETP53POLB | |
| SCHEMBL1938935 | 0.83 | ALDH1A1 (0.39) | MAPTLMNAKDM4ETP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851225-B1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-15 | — | — | EP | claimed |