Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15996813 | 0.78 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TP53NPC1RAB9A | |
| SCHEMBL13977601 | 0.72 | ALDH1A1 (0.50) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| SCHEMBL17690236 | 0.70 | P2RY6 (0.40) | HSD17B10AGTR1AGTR2 | |
| Benzidine SCHEMBL5140469 | 0.63 | CYP3A4 (1.00) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| Benzidine SCHEMBL29021 | 0.63 | CYP3A4 (1.00) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| Benzidine SCHEMBL720393 | 0.63 | CYP3A4 (1.00) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| SCHEMBL258287 | 0.63 | CYP3A4 (1.00) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| SCHEMBL2024128 | 0.63 | CYP3A4 (1.00) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| Benzidine SCHEMBL25274606 | 0.60 | CYP3A4 (0.92) | ALDH1A1CYP3A4TP53TDP1HSD17B10 | |
| Benzidine SCHEMBL9067542 | 0.60 | CYP3A4 (0.92) | ALDH1A1CYP3A4TP53TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256461-B1 | UREA AND SULFONAMIDE DERIVATIVES AS HUMAN HELICASE DDX3 INHIBITORS USEFUL IN THE TREATMENT OF VIRAL DISEASES | AZIENDA OSPEDALIERA UNIV SENESE (IT) | 2023-09-13 | — | — | EP | disclosed |
| EP-3432881-B1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | AZIENDA OSPEDALIERA UNIV SENESE (IT) | 2021-11-24 | — | — | EP | disclosed |
| WO-2017162834-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2017-09-28 | — | — | WO | disclosed |