Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 10/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | TAF1 | P21675 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 4/20 | 0.47 |
| ▸ | RGS12 | O14924 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | BRD1 | O95696 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19405012 | 0.87 | KDM4E (0.59) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19405004 | 0.87 | TAF1 (0.56) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404618 | 0.85 | MEN1 (0.60) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404790 | 0.84 | ALDH1A1 (0.60) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404589 | 0.83 | BRD1 (0.64) | KMT2AMEN1L3MBTL1TAF1MAPT | |
| SCHEMBL19404433 | 0.81 | BRD1 (0.69) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19405025 | 0.81 | BRD1 (0.58) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404627 | 0.81 | TAF1 (0.86) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404444 | 0.81 | TAF1 (0.55) | USP2KMT2AMEN1KEAP1NFE2L2 | |
| SCHEMBL19404469 | 0.80 | TAF1 (0.57) | USP2KMT2AMEN1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162661-A1 | 1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |