Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD1 | O95696 | 11/20 | 0.69 |
| ▸ | USP2 | O75604 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | BRPF1 | P55201 | 10/20 | 0.51 |
| ▸ | TAF1 | P21675 | 10/20 | 0.51 |
| ▸ | RGS12 | O14924 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19404498 | 0.85 | BRD1 (0.69) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19405011 | 0.85 | BRD1 (0.69) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19404624 | 0.83 | BRD1 (0.66) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19404791 | 0.82 | KDM4E (0.65) | BRD1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL19404622 | 0.81 | BRD1 (0.73) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19404603 | 0.81 | BRD1 (0.63) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19404431 | 0.81 | USP2 (0.59) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19404796 | 0.81 | BRD1 (0.63) | BRD1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL19404448 | 0.81 | BRD1 (0.74) | BRD1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL19405026 | 0.80 | BRD1 (0.74) | BRD1USP2KMT2AKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162661-A1 | 1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |