Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16384984 | 0.91 | NQO2 (0.41) | NQO2POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL29587335 | 0.84 | PRKDC (0.48) | POLBL3MBTL1MAPTNPSR1PRKDC | |
| SCHEMBL21403963 | 0.83 | GAA (0.47) | NQO2POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL29885672 | 0.82 | NPC1 (0.56) | POLBL3MBTL1MAPTNPSR1PRKDC | |
| SCHEMBL263749 | 0.82 | NPC1 (0.56) | POLBL3MBTL1MAPTNPSR1PRKDC | |
| SCHEMBL28788044 | 0.82 | HTR2A (0.47) | POLBL3MBTL1MAPTNPSR1TAAR1 | |
| SCHEMBL12706044 | 0.81 | GAA (0.43) | NQO2L3MBTL1MAPTNPSR1ALDH1A1 | |
| SCHEMBL16167828 | 0.81 | L3MBTL1 (0.56) | NQO2POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL20836401 | 0.79 | MAPT (0.50) | NQO2POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL31483694 | 0.79 | MAPT (0.50) | NQO2POLBL3MBTL1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252818-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021252820-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2017165139-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-09-28 | — | — | WO | disclosed |