Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 2/20 | 0.50 |
| ▸ | FNTB | P49356 | 2/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3678518 | 0.93 | SMN1; SMN2 (0.60) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL19404812 | 0.85 | PDE4B (0.60) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL19405234 | 0.85 | PDE4B (0.60) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL31198971 | 0.85 | PDE4B (0.60) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL19405175 | 0.85 | PDE4B (0.63) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL26540027 | 0.84 | SMN1; SMN2 (0.49) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL19405228 | 0.82 | GRIN2B (0.60) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL29087342 | 0.82 | SMN1; SMN2 (0.59) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL26125128 | 0.81 | PDE4B (0.54) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 | |
| SCHEMBL4035554 | 0.80 | SMN1; SMN2 (0.72) | PDE4BSMN1; SMN2RAB9ANPC1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275272-A1 | 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275272-A1 | 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS | AP2A1, P2RX5, AP3M1 | PDE4B 283/4885SMN1; SMN2 4690/4885RAB9A 2103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.