Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14339474 | 0.84 | KDM4E (0.50) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL29979596 | 0.82 | AMY1A (0.39) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL12381475 | 0.82 | AMY1A (0.39) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL27731713 | 0.80 | KDM4E (0.37) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL16704713 | 0.80 | MAPT (0.43) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL4619216 | 0.79 | CA1 (0.46) | KDM4EMAPTMAPK1HTTRAB9A | |
| SCHEMBL22993287 | 0.78 | CA12 (0.48) | KDM4EMAPTMAPK1HTTRAB9A | |
| SCHEMBL16180685 | 0.76 | NOTUM (0.48) | LMNANOTUM | |
| SCHEMBL30715275 | 0.75 | ALDH1A1 (0.46) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL53547 | 0.75 | ALDH1A1 (0.46) | KDM4ES1PR4HSP90AA1MAPTG6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162390-A1 | BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | WO | disclosed |