Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TK1 | P04183 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22815058 | 0.86 | TYMP (0.55) | TYMPMAPK1TK1HPGD | |
| SCHEMBL12956863 | 0.83 | TYMP (0.52) | TYMPMAPK1TK1HPGD | |
| SCHEMBL21100307 | 0.82 | TYMP (0.51) | TYMPMAPK1TK1HPGD | |
| SCHEMBL21783544 | 0.81 | TYMP (0.50) | TYMPMAPK1TK1HPGD | |
| SCHEMBL7139453 | 0.77 | TYMP (0.60) | TYMPMAPK1TK1HPGD | |
| SCHEMBL11472001 | 0.77 | TYMP (0.60) | TYMPMAPK1TK1HPGD | |
| SCHEMBL11472495 | 0.77 | TYMP (0.60) | TYMPMAPK1TK1HPGD | |
| SCHEMBL14944874 | 0.76 | TYMP (0.57) | TYMPMAPK1TK1HPGDGRIA1 | |
| SCHEMBL13498244 | 0.76 | TYMP (0.50) | TYMPMAPK1HPGD | |
| SCHEMBL23873105 | 0.75 | TYMP (0.58) | TYMPMAPK1TK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210154221-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2021-05-27 | — | — | US | disclosed |
| US-10953029-B2 | 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof | MERCK SHARP & DOHME CORP. (US) | 2021-03-23 | — | — | US | disclosed |
| US-20190022115-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2019-01-24 | — | — | US | disclosed |
| US-9777035-B2 | 4′-substituted nucleoside reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210154221-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF | HPRT1, SAMHD1, DUT | TYMP 9/4885MAPK1 2071/4885TK1 104/4885 |
| US-20190022115-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF | HPRT1, DUT, SAMHD1 | TYMP 8/4885MAPK1 1897/4885TK1 88/4885 |
| US-10953029-B2 | 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof | DUT, HPRT1, SAMHD1 | TYMP 7/4885MAPK1 1908/4885TK1 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.