Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501942 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL31026111 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL194130 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL29397364 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL1628799 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6061496 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6062356 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6061494 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL13937393 | 0.84 | TSHR (0.61) | TSHRALDH1A1TRPA1KDM4EMAPT | |
| SCHEMBL136204 | 0.80 | ADRB2 (0.43) | TSHRALDH1A1ADRB2ADRB1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084395-A1 | ENGINEERED NITRILASES FOR BIOCATALYSIS | KCAT ENZYMATIC PRIVATE LIMITED (IN) | 2025-03-13 | — | — | US | claimed |
| CN-118931887-A | Nitrilase cross-linked enzyme aggregate, and preparation method and application thereof | 浙江工业大学 | 2024-11-12 | — | — | CN | claimed |
| CN-118440142-A | Connecting peptide, nitrilase fusion protein and application thereof | 浙江工业大学 | 2024-08-06 | — | — | CN | claimed |
| CN-113754726-B | Recombinant enzyme containing polypeptide tag and application thereof in synthesis of medicinal chemicals | 浙江工业大学 | 2024-03-26 | — | — | CN | claimed |
| CN-113801239-B | Polypeptide tag, highly soluble recombinant nitrilase and application thereof in synthesis of medicinal chemicals | 浙江工业大学 | 2023-10-20 | — | — | CN | claimed |
| WO-2022095221-A1 | POLYPEPTIDE TAG, HIGHLY SOLUBLE RECOMBINANT NITRILASE, AND APPLICATION THEREOF IN PHARMACEUTICAL CHEMICAL SYNTHESIS | 浙江工业大学 | 2022-05-12 | — | — | WO | claimed |
| US-20220135960-A1 | POLYPEPTIDE TAG, HIGHLY SOLUBLE RECOMBINANT NITRILASE AND APPLICATION THEREOF IN SYNTHESIS OF PHARMACEUTICAL CHEMICALS | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2022-05-05 | — | — | US | claimed |
| EP-3875594-A1 | PREPARATION METHOD FOR (R)-O-CHLOROMANDELIC ACID AND CYCLIC BIOENZYME CATALYTIC REACTION SYSTEM FOR THE PREPARATION METHOD | Wuhan Wuyao Pharmaceutical Co., Ltd. (CN) | 2021-09-08 | — | — | EP | claimed |
| EP-2092060-B1 | R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS | DSM IP ASSETS BV (NL) | 2014-01-22 | — | — | EP | claimed |
| US-7985572-B2 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF SE (DE) | 2011-07-26 | — | — | US | claimed |
| CN-1635129-A | Process for preparing optical active cyanalcohol through enzyme catalysis alcoholysis reaction resolution | UNIV ZHEJIANG (CN) | 2005-07-06 | — | — | CN | claimed |
| WO-2004076655-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-10 | — | — | WO | claimed |
| US-20040038419-A1 | Assays and kits for detecting the presence of nitriles and/or cyanide | DIVERSA CORPORATION | 2004-02-26 | — | — | US | claimed |
| WO-2003098187-A2 | ASSAYS AND KITS FOR DETECTING THE PRESENCE OF NITRILES AND/OR CYANIDE | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | claimed |
| EP-0610048-B1 | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | MITSUBISHI RAYON CO (JP) | 1999-09-22 | — | — | EP | claimed |
| EP-0527553-B1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO LTD (JP) | 1997-05-07 | — | — | EP | claimed |
| US-5580765-A | A CULTURE PRODUCT OF A-HYDROXYNITRILE OR A MIXTURE OF ALDEHYDE AND PRUSSIC ACID | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-03 | — | — | US | claimed |
| EP-0610048-A2 | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-08-10 | — | — | EP | claimed |
| US-5296373-A | Stereoselective hydrolysis of mandelonitrile in neutral or basic aqueous medium | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-03-22 | — | — | US | claimed |
| EP-0527553-A1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-02-17 | — | — | EP | claimed |