Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501942 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL31026111 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL194129 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL29397364 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL1628799 | 1.00 | TSHR (0.50) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6061496 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6062356 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL6061494 | 0.92 | ALDH1A1 (0.45) | TSHRALDH1A1ADRB2ADRB1AOC3 | |
| SCHEMBL13937393 | 0.84 | TSHR (0.61) | TSHRALDH1A1TRPA1KDM4EMAPT | |
| SCHEMBL136204 | 0.80 | ADRB2 (0.43) | TSHRALDH1A1ADRB2ADRB1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2092060-B1 | R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS | DSM IP ASSETS BV (NL) | 2014-01-22 | — | — | EP | claimed |
| CN-118308316-A | Biocatalysis asymmetric reaction reductase and application thereof | 湖州师范学院 | 2024-07-09 | — | — | CN | disclosed |
| CN-111057696-B | Hydroxynitrile lyase mutant and application thereof in synthesis of (R) -salmeterol | 华东理工大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-112852790-B | Plant nitrilase chimeric enzyme mutant, coding gene and application thereof | 浙江工业大学 | 2022-04-29 | — | — | CN | disclosed |
| CN-112626057-B | Chimeric plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2022-03-08 | — | — | CN | disclosed |
| CN-112852790-A | Plant nitrilase chimeric enzyme mutant, coding gene and application thereof | 浙江工业大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-112626057-A | Chimeric plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2021-04-09 | — | — | CN | disclosed |
| CN-110714002-B | Plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2021-03-26 | — | — | CN | disclosed |
| CN-111057696-A | Hydroxynitrile lyase mutant and application thereof in synthesis of (R) -salmeterol | 华东理工大学 | 2020-04-24 | — | — | CN | disclosed |
| CN-110714002-A | Plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2020-01-21 | — | — | CN | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |
| US-20020052039-A1 | Process for preparing an enzyme extract | CLARIANT GMBH | 2002-05-02 | — | — | US | disclosed |
| US-20020052523-A1 | Process for preparing optically active cyanohydrins and secondary products | CLARIANT GMBH | 2002-05-02 | — | — | US | disclosed |
| US-20020006646-A1 | Enzyme reaction method and a method for enzymatically producing an optically active cyanohydrin | NIPPON SHOKUBAI CO., LTD. | 2002-01-17 | — | — | US | disclosed |
| EP-1160235-A2 | A method for producing alpha-hydroxycarboxylic acid | Nippon Shokubai Co., Ltd. (JP) | 2001-12-05 | — | — | EP | disclosed |
| EP-1160329-A2 | An enzyme reaction method and a method for enzymatically producing an optically active cyanohydrin | Nippon Shokubai Co., Ltd. (JP) | 2001-12-05 | — | — | EP | disclosed |
| US-20010041359-A1 | Process for the preparation of optically and chemically highly pure (R) - or (S) -alpha- hydroxycarboxylic acids | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2001-11-15 | — | — | US | disclosed |
| EP-0449648-B1 | Process for producing R(-)-mandelic acid and derivatives thereof | NITTO CHEMICAL INDUSTRY CO LTD (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5223416-A | Subjecting mandelonitrile or derivative thereof, or mixture of prussic acid and benzaldehyde or derivative thereof to stereospecific hydrolysis by microorgansim | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0449648-A2 | Process for producing R(-)-mandelic acid and derivatives thereof | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052523-A1 | Process for preparing optically active cyanohydrins and secondary products | DOHH, OGDH, AOX1 | TSHR 3944/4885ALDH1A1 159/4885ADRB2 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.