Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.53 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.40 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19425343 | 0.89 | MCL1 (0.58) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL3425202 | 0.88 | MCL1 (0.62) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL13461379 | 0.85 | MCL1 (0.57) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL3422932 | 0.85 | MCL1 (0.56) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL3422938 | 0.85 | MCL1 (0.56) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL3422944 | 0.85 | MCL1 (0.56) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL13461491 | 0.84 | MCL1 (0.52) | MCL1BAK1BCL2L1PTPN1ADAMTS5 | |
| SCHEMBL3427111 | 0.80 | MYC (0.51) | ADAMTS5MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3427113 | 0.80 | MYC (0.51) | ADAMTS5MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19420037 | 0.80 | MCL1 (0.52) | MCL1BAK1BCL2L1PTPN1ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | MCL1 137/4885BAK1 524/4885BCL2L1 953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.