Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.59 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | CLK3 | P49761 | 1/20 | 0.58 |
| ▸ | MELK | Q14680 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421279 | 0.83 | PDE4B (1.00) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL8171885 | 0.83 | PDE4B (1.00) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL8171882 | 0.83 | PDE4B (1.00) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3427116 | 0.82 | MYC (0.51) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3427111 | 0.82 | MYC (0.51) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3427113 | 0.82 | MYC (0.51) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3424781 | 0.79 | PDE4B (0.61) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3424778 | 0.79 | PDE4B (0.61) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL8307071 | 0.79 | PDE4B (1.00) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL8308532 | 0.79 | PDE4B (1.00) | PDE4BPDE3ADYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | PDE4B 1328/4885PDE3A 3146/4885DYRK1A 4359/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | PDE4B 1787/4885PDE3A 3194/4885DYRK1A 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.