Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 14/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19429334 | 1.00 | DOT1L (0.46) | DOT1LPRMT5WDR77PRMT7EZH2 | |
| SCHEMBL17551923 | 0.74 | USP2 (0.47) | — | |
| SCHEMBL19429331 | 0.73 | ALB (0.46) | — | |
| SCHEMBL31533321 | 0.71 | FOLH1 (0.42) | DOT1L | |
| SCHEMBL19434125 | 0.69 | DOT1L (0.77) | DOT1LPRMT7 | |
| SCHEMBL19429335 | 0.69 | DOT1L (0.77) | DOT1LPRMT7 | |
| SCHEMBL10145861 | 0.69 | USP2 (0.52) | — | |
| SCHEMBL19433799 | 0.69 | DOT1L (0.77) | DOT1LPRMT7 | |
| SCHEMBL31001524 | 0.69 | CA12 (0.50) | — | |
| SCHEMBL31001589 | 0.69 | CA1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183965-B2 | Cofactor analogues for methyltransferases | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2019-01-22 | — | — | US | disclosed |
| US-20170283453-A1 | COFACTOR ANALOGUES FOR METHYLTRANSFERASES | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183965-B2 | Cofactor analogues for methyltransferases | BHMT, BHMT2, NNMT | DOT1L 44/4885PRMT5 57/4885WDR77 640/4885 |
| US-20170283453-A1 | COFACTOR ANALOGUES FOR METHYLTRANSFERASES | BHMT, BHMT2, NNMT | DOT1L 50/4885PRMT5 64/4885WDR77 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.