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BHMT2

S-methylmethionine--homocysteine S-methyltransferase BHMT2 · Q9H2M3 · BHMT2 on Sugi Atlas →

1,874 patent compounds predicted against BHMT2, 1,611 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1031684 SCHEMBL1031684 0.73 1/20
SCHEMBL1031686 SCHEMBL1031686 0.73 1/20
SCHEMBL474910 SCHEMBL474910 0.67 1/20
SCHEMBL474911 SCHEMBL474911 0.67 1/20
SCHEMBL2119412 SCHEMBL2119412 0.67 1/20
Ethionine Ethionine (SCHEMBL8966) 0.63 1/20
Ethionine Ethionine (SCHEMBL8967) 0.63 1/20
SCHEMBL1199871 SCHEMBL1199871 0.63 1/20
SCHEMBL4300941 SCHEMBL4300941 0.63 1/20
SCHEMBL6500979 SCHEMBL6500979 0.63 1/20
Ethionine Ethionine (SCHEMBL7073863) 0.63 1/20
SCHEMBL7271061 SCHEMBL7271061 0.63 1/20
SCHEMBL7271063 SCHEMBL7271063 0.63 1/20
SCHEMBL60520 SCHEMBL60520 0.62 1/20
SCHEMBL1285565 SCHEMBL1285565 0.62 1/20
Ethionine Ethionine (SCHEMBL4763197) 0.62 1/20
SCHEMBL4955426 SCHEMBL4955426 0.62 1/20
SCHEMBL3860784 SCHEMBL3860784 0.62 1/20
SCHEMBL3860789 SCHEMBL3860789 0.62 1/20
SCHEMBL1900523 SCHEMBL1900523 0.61 1/20

Clinical trials — most relevant to BHMT2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic PHASE4COMPLETED
Efficacy Study of Folic Acid Supplementation in Adolescent Epileptics PHASE3UNKNOWN
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters. PHASE2/PHASE3UNKNOWN
Serine Supplementation for Obese Subjects With Fatty Liver Disease PHASE1/PHASE2COMPLETED
Folate Rechallenge PHASE2COMPLETED
Betaine METABOLISM OF PATIENTS With Homocystinuria PHASE2COMPLETED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine PHASE1COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism nanCOMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias nanUNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Early Nutritional Intervention in Patients With Autism Spectrum Disorders nanCOMPLETED
Harmonized Micronutrient Project nanCOMPLETED
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan nanWITHDRAWN
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Study of Neurological Complication After Radiotherapy for High Grade Glioblastoma nanUNKNOWN
Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma nanUNKNOWN
Study of Homocysteine Metabolism in Homocystinuria nanCOMPLETED
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease nanUNKNOWN
DNA Methylation and Arsenic-associated Urothelial Carcinoma nanUNKNOWN
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria nanCOMPLETED
Homocysteine and Coronary Artery Disease nanCOMPLETED
Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study nanRECRUITING
Plasma S-adenosylhomocysteine Levels and Endothelial Dysfunction nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a BHMT2 binder may also engage these)

ProteinNameSimilarity
Q5RF32 — 1.000 Q5RF32 →
Q68FT5 — 1.000 Q68FT5 →
Q91WS4 — 0.999 Q91WS4 →
Q5XGM3 — 0.994 Q5XGM3 →
Q5M8Z0 — 0.993 Q5M8Z0 →
Q32LQ4 — 0.990 Q32LQ4 →
Q5RFG2 — 0.989 Q5RFG2 →
O09171 — 0.987 O09171 →
BHMT Betaine--homocysteine S-methyltransferase 1 0.983 landscape →
O35490 — 0.980 O35490 →
A7M6E8 — 0.975 A7M6E8 →
Q5I597 — 0.973 Q5I597 →
A7M6E7 — 0.971 A7M6E7 →
Q5R514 — 0.966 Q5R514 →
Q9FUM9 — 0.966 Q9FUM9 →
Q53JY8 — 0.965 Q53JY8 →
Q9FUM8 — 0.964 Q9FUM8 →
Q95332 — 0.963 Q95332 →
B4G0F3 — 0.962 B4G0F3 →
Q5I598 — 0.962 Q5I598 →
O80526 — 0.961 O80526 →
UMPS Uridine 5'-monophosphate synthase 0.961 landscape →
P31754 — 0.961 P31754 →
Q5RAK7 — 0.961 Q5RAK7 →
Q9HD40 — 0.960 Q9HD40 →
Q94AR8 — 0.959 Q94AR8 →
Q803A7 — 0.959 Q803A7 →
P42898 — 0.959 P42898 →
Q5RAT4 — 0.959 Q5RAT4 →
P13439 — 0.959 P13439 →