Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436968 | 1.00 | MAPT (0.52) | MAPTPOLBAKR1C2ALDH1A1LMNA | |
| SCHEMBL6576793 | 0.85 | AKR1C2 (0.56) | POLBAKR1C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4333508 | 0.83 | ALDH1A1 (0.51) | MAPTAKR1C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4333500 | 0.83 | ALDH1A1 (0.51) | MAPTAKR1C2ALDH1A1KMT2AMEN1 | |
| SCHEMBL2008011 | 0.80 | AR (0.64) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL2008010 | 0.80 | AR (0.64) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL10693625 | 0.80 | AR (0.64) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL12486667 | 0.79 | MAPT (0.62) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL16740642 | 0.78 | ABCG2 (0.76) | MAPTALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL14318105 | 0.78 | ABCG2 (0.76) | MAPTALDH1A1LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176930-A1 | DIPHENYLACRYLIC ACID DERIVATIVES THAT PROMOTE BONE AND CARTILAGE GROWTH | EMORY UNIVERSITY (US) | 2017-10-12 | — | — | WO | claimed |