Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436960 | 0.86 | AKR1C2 (0.56) | AKR1C2NPC1POLBAKR1C1CA12 | |
| SCHEMBL19436961 | 0.86 | AKR1C2 (0.56) | AKR1C2NPC1POLBAKR1C1CA12 | |
| SCHEMBL19436968 | 0.85 | MAPT (0.52) | AKR1C2POLBABCG2MEN1KMT2A | |
| SCHEMBL19436969 | 0.85 | MAPT (0.52) | AKR1C2POLBABCG2MEN1KMT2A | |
| SCHEMBL8474827 | 0.84 | CA12 (0.55) | AKR1C2NPC1POLBABCG2CA12 | |
| SCHEMBL8474824 | 0.84 | CA12 (0.55) | AKR1C2NPC1POLBABCG2CA12 | |
| SCHEMBL8730398 | 0.82 | CTNNB1 (0.56) | AKR1C2AKR1C1MEN1KMT2AALDH1A1 | |
| SCHEMBL1646802 | 0.82 | AKR1C1 (0.69) | AKR1C2POLBAKR1C1MEN1KMT2A | |
| SCHEMBL6672796 | 0.82 | MAPT (0.62) | AKR1C2NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL11504802 | 0.81 | AR (0.52) | AKR1C2NPC1POLBABCG2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458695-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-09-22 | — | — | EP | disclosed |
| EP-1446390-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003057679-A9 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE (US) | 2004-02-26 | — | — | WO | disclosed |
| WO-2003057679-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003042195-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-05-22 | — | — | WO | disclosed |