Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19441984 | 0.84 | HDAC4 (0.48) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL28817917 | 0.80 | HDAC4 (0.57) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL992096 | 0.79 | MEN1 (0.63) | HDAC4HDAC6TSHRALDH1A1TDP1 | |
| SCHEMBL28817945 | 0.78 | ALDH1A1 (0.47) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL19825337 | 0.78 | TSHR (0.45) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL19825409 | 0.76 | TSHR (0.44) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL19442031 | 0.76 | HTT (0.40) | HDAC4HDAC6HTTTSHRALDH1A1 | |
| SCHEMBL19442049 | 0.76 | HTT (0.58) | HTTTSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL11985077 | 0.75 | TSHR (0.50) | TSHRALDH1A1TDP1PDE4DKMT2A | |
| SCHEMBL19825336 | 0.75 | TSHR (0.43) | HDAC4HDAC6HTTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |