Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19825337 | 0.85 | TSHR (0.45) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL19825410 | 0.85 | L3MBTL1 (0.35) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL19825336 | 0.83 | TSHR (0.43) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL28817917 | 0.81 | HDAC4 (0.57) | TSHRALDH1A1GLAKMT2AHTT | |
| SCHEMBL28817945 | 0.79 | ALDH1A1 (0.47) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL19442031 | 0.77 | HTT (0.40) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL19442049 | 0.77 | HTT (0.58) | TSHRALDH1A1KMT2AHTTL3MBTL1 | |
| SCHEMBL19442076 | 0.76 | HDAC4 (0.41) | TSHRALDH1A1GLATDP1KMT2A | |
| SCHEMBL19441984 | 0.76 | HDAC4 (0.48) | TSHRALDH1A1GLAHTTHDAC4 | |
| SCHEMBL11985077 | 0.76 | TSHR (0.50) | TSHRALDH1A1TDP1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018022797-A1 | DERMATOLOGICAL FORMULATIONS OF 2-(2-ETHOXY-2-OXOETHYL)(METHYL)AMINO-2-OXOETHYL 5-(TETRADECYLOXY)FURAN-2-CARBOXYLATE | DERMIRA INC. (US) | 2018-02-01 | — | — | WO | disclosed |